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Half the people who have panic disorder don't seek help, and when they do seek help, they often go to the emergency room, or to medical professionals. Why is this? Panic is easily confused with having a heart attack. It's so physical in nature, that the even the professionals rarely diagnosis it appropriately.
Panic disorder wreaks havoc on the lives of those who suffer from it. It is chronic and it's long lasting. It can develop into other issues such as depression and it also associated with suicidal ideation although we don't fully understand this connection.
This page is a summary of evidenced based best practice for panic disorder medicine as described in the research journals. It may have changed by the time your read it. I am not a psychiatrist or doctor, and your doctor may explain things differently or give you contrary information. The important thing is that you understand from YOUR doctor why medications are prescribed and can make sense of the plan that you are currently on or the information you are offered. If you have panic attacks use this as a guide to ask thoughtful questions of your doctor about why you are prescribed the medications you are and/ or about what the next steps are if your panic attack medicine isn't working.
Antidepressants. Selective serotonin reuptake inhibitors (SSRI's)
SSRI's are those meds that act on the serotonergic system. these include:
All of these drugs work to help panic attacks, so when doctors are choosing between these drugs, they have to consider several issues.
Below summarizes what the research says a doctor should likely consider when first deciding what panic attack medicine to prescribe for you.
Benzodiazepines work very quickly and most people will continue to take them despite the side effects. However, they are ineffective with other conditions such as depression and can cause dependence ( addiction).
They are not recommended in the literature guidelines generally as a first choice of treatment for panic attacks. Of course, we find they are often prescribed.
TCA's take a longer time than SSRI's to begin working,have worse side effects and are less safe. More people who take TCA's will discontinue therapy when they are prescribed them. They are not recommended in guidelines as a first choice for evidence based practice.
Phenelzine has serious side effects , many risks and high drop out rates so would not be considered unless other medicines had been tried and failed.
SSRI's or SNRI's ( Venlafaxine). The side effect profile, success in long treatment, success in treating comorbid depression, all suggest these two would be the first choices for a person presenting at the doctor's office for medications for panic disorder. Generally, these are recommended as the best practice for panic attack medicines. However...
Unfortunately SSRIs, TCAs and Venlafaxine, all of have the potential to exacerbate anxiety and panic early in the treatment course.
For almost all antidepressants, the length of time it will take for them to work is several weeks. In our culture and society this is a diffiuclt thing, especially if you are having panic attacks, which can be scary and unpleasant.
Doctors will sometimes prescribe a benzodiazepine along with the antidepressant to lessen these symptoms, this is recommended as good practice to help with the side effects.
Unfortunately, it doesn't appear that being on panic attack medicine cures them.
If you go for treatment and you don't respond to your doctors choices of medications, you fall into a special category called treatment refractory. Then the doctor can make some special choices. The doctor might
Note it may be important to ask your doctor about the medication choices and your other diagnosis. If you have a diagnosis in addition to panic disorder, and your panic attacks are a part of that disorder, it will change how your medicine is prescribed.
Batelaan, N., Van Balkom, A., & Stein, D. (2011). Evidence-based pharmacotherapy of panic disorder: an update. The International Journal Of Neuropsychopharmacology, 15(03), 403-415. doi: 10.1017/s1461145711000800
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